Microbiome & Cancer Group

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Antonia Sophocleous

Group Leader - Coordinator of BSc Biological Sciences
Assistant Professor, Biochemistry
Department of Life Sciences
European University Cyprus

Short Bio:

Dr Antonia Sophocleous is currently an Assistant Professor in Biochemistry at the European University Cyprus. She holds a PhD in Molecular Medicine (University of Edinburgh). Her background is in Molecular Biology and Biochemistry (BSc Hons, Durham University) and her research focuses mainly on bone metabolism. She has been a Post-Doctoral Research Fellow for a number of years at the Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, mainly investigating the role of the endocannabinoid system in bone health, and the prospect of cannabinoid receptors as novel molecular targets for the treatment of osteoporosis and other bone diseases. More recently she developed a research interest in the role of the gut microbiome in the pathophysiology of osteoarthritis and in cancer development and therapy. Since June 2021 Dr Sophocleous is the Leader of the “Microbiome and Cancer” Group. The main focus of her research group is to investigate the influence of the gut microbiome on gastrointestinal and extraintestinal cancers and in particular to examine the tumour-suppressive effects of Lactobacillus strains on proliferation, migration, and invasion of malignant cells. She has published in total 23 original research, peer-reviewed articles in reputed journals (fifteen [15] Q1 journals and one [1] Q2 journal), 10 of which are first-author manuscripts. In addition, she has written 3 book chapters in the most recent edition of the Bone Research Protocols book – Methods in Molecular Biology. According to Scopus, Dr Sophocleous has more than 500 total citations (h-index: 12). She has participated in 20 national and international conferences to present her research work either in oral or poster presentations. She is an instructor for the undergraduate programmes of Biological Sciences, Biomedical Sciences, Pharmacy and Nutrition & Dietetics. She has supervised to completion one (1) PhD student (co-supervisor, University of Edinburgh), three (3) postgraduate students (MSc Clinical Trials, University of Edinburgh) and fourteen (14) undergraduate students (BSc Biological Sciences and BSc Pharmacy, European University Cyprus). She is a reviewer for several Bone-specific scientific journals; a Co-Chair for the Editorial Board of HubLE Methods Committee (part of the IFMRS – International Federation of Musculoskeletal Research Societies), which produces bone-related protocols; she is a Management Committee Substitute member of Cyprus for the GEMSTONE (Genomics of MusculoSkeletal traits Translational Network) – CA18139 COST Action; and a Co-Editor of ECTS (European Calcified Tissue Society) Newsletter. 

Research focus:

The main focus of the Microbiome and Cancer Group is to investigate the influence of the gut microbiome on gastrointestinal cancers. Over the past few years evidence has shown that dietary supplementation with probiotics is necessary to promote the development of beneficial microbiota in the intestine and thereby a healthy gut microbiome. In light of this, the Microbiome and Cancer Group is examining the tumour-suppressive effects of Lactobacillus strains. In particular, we are investigating whether secreted soluble factors from certain Lactobacillus strains prevent proliferation, migration, and invasion of malignant cells from the gastrointestinal tract.

Current Group Members

Andrea Christou_photo

Andrea Christou

BSc
MSc student,
Her main research interests include the identification of the therapeutic effects of zoledronic acid on osteosarcoma progression and metastasis through a comprehensive systematic review and meta-analysis.
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Maria-Victoria Tsangara

BSc
BSc student,
Her main research interests include the correlation of hepatocellular carcinoma and intestinal microbiome dysbiosis through clinical evidence.
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Ioannis Papachristodoulos

BSc
BSc student,
His main research interests include investigating intestinal microbiome changes after anti-cancer treatment for breast cancer.
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Maria Nicolaou

BSc
BSc student,
Her main research interests include investigating the role of the intestinal microbiome in the treatment of prostate cancer.
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Kyriaki Gerorgiou

BSc
BSc student,
Her main research interests include investigating the potential efficacy of probiotics in the treatment of breast cancer.
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Andriani Papandreou

BSc
BSc student,
Her main research interests include investigating the potential efficacy of probiotics in the treatment of breast cancer.

Past Group Members

Christiana Papadaki

BSc student
Her main research interests include the in vitro investigation of the effects of probiotic secreted factors on the viability of chondrocytes

Maria Moyseos

BSc, (2020)
BSc Thesis Title: The anti-inflammatory action of probiotics on the skeleton.
Current position: MSc student

Elena Theodoraki

BSc, (2020)
BSc Thesis Title: Therapeutic effects of cannabinoids on the skeleton: systematic review and meta‐analysis of pre-clinical and clinical studies.

Thelma Hadjiantoniou

BSc student
Her main research interests include the review of the efficacy of gut microbiome as treatment for type 2 diabetes

Maria Papagianni

BSc, (2020)
BSc Thesis Title: Is medical cannabis an appropriate opioid substitute?

Elena Vrachimi

BSc, (2020)
BSc Thesis Title: Use of medicinal cannabis during pregnancy and breast-feeding

Maristella Charalambous

BSc student
Her main research interests include the review of the metabolomic analysis as a tool for osteoarthritis research

Evelina - Jasmin Petrikkou

BSc, (2020)
BSc Thesis Title: Mechanisms of action of probiotics and prebiotics

Jenny Michael

BSc student
Her main research interests include the identification of the anti-inflammatory effects of probiotics on the skeleton through a comprehensive systematic review and meta-analysis

Constantinos Christodoulides

BSc, (2020)
BSc Thesis Title: Clinical evidence for the effectiveness of medical cannabis in chronic pain

Eleni Stylianou

BSc, (2019)
BSc Thesis Title: Probiotic therapy in mice with induced arthritis. Current position: MSc student

Vasiliki Devetzi

BSc student
Her main research interests include the review of in vivo models and in vitro experiments for the study of Rheumatoid Arthritis

Constantina Ellina

BSc, (2019)
BSc Thesis Title: The role of probiotics and prebiotics in the treatment and prevention of osteoarthritis

Savvina Panayiotou

BSc, (2019)
BSc Thesis Title: The role of probiotics and prebiotics in the treatment and prevention of osteoporosis

Panagiota Pantela

BSc student
Her main research interests include the review of evidence for the use of cannabidiol as an anti-epileptic treatment

Research Grants

Ongoing

Completed

University of Edinburgh, Centre for Genomic and Experimental Medicine internal funding (2016-2017). Role: Project Coordinator. Title: “The role of microbiome in osteoarthritis development”.

Arthritis Research UK (19799, 01/08/2012 – 31/12/2016). Role: Post-Doctoral research fellow employed on the grant. Title: “Genetic and Environmental Determinants of Paget’s Disease”.

 

Arthritis Research UK (17713, 02/01/2008 – 01/07/2015). Role: Post-Doctoral research fellow employed on the grant. Title: “Regulation of bone metabolism by cannabinoid receptors: mechanisms of action and implications for the treatment of bone disease”.

 

Selected Publications

Full list of publications

Collaborators

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