Cancer Genetics, Genomics & Systems Biology group
Coordinator of BSc Biological Sciences
Department of Life Sciences
European University Cyprus
Dr. Apostolos Zaravinos is a Professor of Cancer Genetics and the group leader of the “Cancer Genetics, Genomics & Systems Biology” group of the Basic and Translational Cancer Research Center (BTCRC). He is also the coordinator of the program “BSc in Biological Sciences” in the Department of Life Sciences at the European University Cyprus. He received his B.Sc. in Biology from the Department of Biology, University of Crete, and his Ph.D. in Medicine from the Medical School of the same University. He worked as Research Scientist at the Harris Birthright Research Center for Fetal Medicine, King’s College Hospital, and performed postdoctoral research in Cancer Genetics at the Molecular Medicine Research Center, University of Cyprus. He completed his postdoctoral training in Immunogenetics and Cancer Genetics at the Department of Laboratory Medicine, Karolinska Institute. In addition, he worked as an Associate Professor in Genetics in the Department of Basic Medical Science, at the College of Medicine, Qatar University. Dr. Zaravinos holds two Specialisations: one in “Systems Biology” from the Systems Biology Center at Icahn School of Medicine, Mount Sinai, and another in “Genomic Data Science” from the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University. He is a member of the Editorial Board of BMC Cancer, International Journal of Molecular Sciences, Frontiers in Oncology, and Frontiers in Pharmacology, among others. He has worked as a Guest Editor for several Special Issues in scientific journals and as an Associate Faculty Member of the F1000Prime. In 2020, 2021, and 2022 he was included in the list of the top 2% of the world’s most-cited and influential in their main subfield discipline scholars, on a global list compiled by Stanford University. He is the recipient of the Science Award from the Youth Board of Cyprus, and the first Young Investigator Award from the Bank of Cyprus Oncology Centre. He is a member of the EACR, AACR, and FEBS and an elected member of the Society of Biological Sciences in Cyprus (SBSCy) board. He has published >115 papers in refereed journals and 7 book chapters (h-index, 39; i10-index, 78; >4900 citations; Google Scholar). His research work aims toward the advanced understanding of carcinogenesis through the investigation of interactions across genes, the discovery of therapeutic targets, and the examination of the immune landscape in inflamed tumors.
Our research group is focusing on the advanced understanding of carcinogenesis through the investigation of interactions across genes. Current major interests include the discovery of therapeutic targets in cancer using next-generation sequencing approaches and the investigation of how gene expression is regulated in cancer. We are also interested in the examination of the immune landscape in inflamed tumors, aiming to find out how this relates to various aspects of their biology. We are especially interested in identifying new links between distinct genomic events, such as kataegis and chromothripsis, and the activation of an antitumor immune response in cancer. We are also keen on elucidating the fractions of different immune cells and cancer neoantigens, and predicting patient responsiveness to immune checkpoint inhibitors. The aim of our research is to produce new knowledge that can be used to provide better therapeutic guidance to cancer patients.
Current Group Members
Paraskevi (Evita) Vryza
Past Group Members
Rebecca Emily Hill
Andria Zoppi & Zacharo Zacharia
Dr. Beatriz de Lucas Moreno
HORIZON Call: DIGITAL-2022-TRAINING-02 (Digital Training). Topic: DIGITAL-2022-TRAINING-02-SHORT-COURSES. Type of Action: DIGITAL-SME (01/01/2023 – 30/12/2026). Title: “LEVEraging knowLedge of training providers in UPskilling and reskilling of SMEs’ managers and employees towards empowering their digital transformation (Level Up)”. Funding: 4.838,991.54 € (449,721.00 € to European University Cyprus)
Research & Innovation Foundation’s Program, (EXCELLENCE 0421/0179, 01/03/2021 – 28/02/2023), Role: Partner, Title: “Targeting the desmoplastic tumor microenvironment to improve the efficacy of pancreatic cancer immunotherapy”.
Cyprus Research Promotion Foundation, (EXCELLENCE/1216/0417), Role: Partner, Title: “Genetic modifiers in Alport syndrome and thin basement membrane nephropathy”.
Cyprus Research Promotion Foundation, (ENTERPRISES/0916/0083), Role: Partner, Title: “Donkey Milk Bioactive Powder”.
Research Promotion Foundation’s Program – Co-funded by the European Regional Development Fund and the Republic of Cyprus, (POST-DOC/0916/0154). Role: Project Coordinator. Title: “Investigation of RNA editing in microRNA targeting in cancer” (gracefully turned down).
Cyprus Research Promotion Foundation, (EXCELLENCE 1216/0036, 01/09/2018 – 31/08/2021), Role: Partner, Title: “Functional and therapeutic implications of histone N-terminal acetyltransferase Naa40 in colorectal oncogenesis”.
Karolinska Institutet’s 2014 Research Foundation Grant (Karolinska Institutets Forskningsstiftelser 2014). Project title: RNA sequencing of diffuse large B-cell lymphoma (2014fobi41242).